In spite of is used as a preposition; it means more or less the same as although + clause:
We went out in spite of the rain = ... although it was raining
We understood him in spite of his accent = ... although he had a strong accent
In spite of is the opposite of because of. Compare:
She passed her exams in spite of her teacher. (She had a bad teacher)
She passed her exams because of her teacher. (She had a good teacher)
In spite of can be followed by an -ing form:
In spite of having a headache I enjoyed the film.
She failed the exam in spite of having worked very hard
In more formal English, despite can be used in the same way as in spite of.
Here is a link to a quiz about using despite and other related conjunctions. Feel free to do it!
Although, Though, Despite and However
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